Antiemetics
Metoclopramide
Absolute Contraindications
- Parkinson’s disease
- GI obstruction
Main Side Effects
- Dystonic reactions (especially in young adults)
- Diarrhoea
Main Interactions
- Antipsychotics (additive extrapyramidal side effects)
Main Monitoring Requirements
- Symptoms of extrapyramidal reactions
Pregnancy & Breastfeeding
- Safe
Ondansetron
Absolute Contraindications
- Congenital long QT syndrome
Main Side Effects
- Constipation
- QT prolongation
Main Interactions
- Drugs prolonging QT interval
Main Monitoring Requirements
- ECG in high-risk patients
Pregnancy & Breastfeeding
- Safe
Cyclizine
Absolute Contraindications
- Severe liver disease
Main Side Effects
- Drowsiness
- Dry mouth Main Interactions
- CNS depressants (additive sedation)
Main Monitoring Requirements
- Sedation and anticholinergic effects Pregnancy & Breastfeeding
- Limited data but considered relatively safe
Domperidone
Absolute Contraindications
- Prolactinoma
- QT prolongation
Main Side Effects
- QT prolongation
- Headache
Main Interactions
Drugs prolonging QT interval Main Monitoring Requirements
- ECG in high-risk patients
Pregnancy & Breastfeeding
- Avoid unless benefits outweigh risks
Promethazine
Absolute Contraindications
- Severe CNS depression
Main Side Effects
- Drowsiness
- Anticholinergic effects Main Interactions
- CNS depressants (additive sedation)
Main Monitoring Requirements
- Sedation and anticholinergic effects Pregnancy & Breastfeeding
- Safe for short-term use
Prochlorperazine
Absolute Contraindications
- CNS depression
- Severe liver disease Main Side Effects
- Extrapyramidal symptoms
- Drowsiness
Main Interactions
- CNS depressants (additive sedation)
Main Monitoring Requirements
- Symptoms of extrapyramidal reactions
Pregnancy & Breastfeeding
- Safe for short-term use