Biological Agents (e.g., Adalimumab, Infliximab)
Absolute Contraindications
- Active or untreated infections (e.g., tuberculosis)
- Moderate to severe heart failure (for some agents)
Main Side Effects
- Injection site reactions
- Increased risk of infections
- Rare: Demyelinating disorders
Main Interactions
- Live vaccines (e.g., MMR, yellow fever)
Main Monitoring Requirements
- Baseline screening for infections (e.g., TB, hepatitis)
- Regular monitoring for infections and malignancies
Pregnancy & Breastfeeding
- Some agents (e.g., adalimumab) can be used in pregnancy; breastfeeding depends on the agent