Proton Pump Inhibitors (e.g., Omeprazole, Lansoprazole)
Absolute Contraindications
- Nonspecific; hypersensitivity to PPIs
Main Side Effects
- GI disturbances (nausea, diarrhoea)
- Hypomagnesaemia with long-term use
- Increased risk of fractures (long-term use reduces BMD)
Main Interactions
- Clopidogrel (reduced efficacy)
- Warfarin (altered INR in some cases)
Main Monitoring Requirements
- Magnesium levels with long-term use
Pregnancy & Breastfeeding
- Generally considered safe