SSRIs (e.g., Sertraline, Citalopram, Fluoxetine)
Absolute Contraindications
- Concurrent use of MAOIs
- QT prolongation (with high doses of citalopram/escitalopram)
Main Side Effects
- GI upset (nausea, diarrhoea)
- Sexual dysfunction
- Risk of serotonin syndrome (with other serotonergic drugs) Main Interactions
- NSAIDs (risk of GI bleeding)
- Triptans or other serotonergic drugs (risk of serotonin syndrome)
Main Monitoring Requirements
- Monitor for worsening depression / suicidal ideation during initiation
Pregnancy & Breastfeeding
- Use cautiously in pregnancy. Sertraline often preferred in breastfeeding