DOACs (e.g., Apixaban, Rivaroxaban, Dabigatran)
Absolute Contraindications
- Active bleeding & bleeding disorders
- Pregnancy and breastfeeding
- <16 yrs old (Reye’s syndrome)
Main Side Effects
- Bleeding
- GI upset (especially dabigatran)
Main Interactions
- Antiplatelets, NSAIDs (additive bleeding risk)
- Strong CYP3A4 inhibitors (e.g., ketoconazole)
Main Monitoring Requirements
-
- No routine monitoring; renal function periodically
Pregnancy & Breastfeeding
- Avoid