Definition
OTHER MYELOPROLIFERATIVE DISORDERS
Definition
- Proliferation of one or more haematopoietic components in bone marrow
Associated Conditions
- Essential thrombocythemia
- Polycythaemia vera – MENTIONED IN OTHER TOPIC
- Myelofibrosis
- Chronic myeloid leukaemia – MENTIONED IN OTHER TOPIC
Essential Thrombocythemia – Features:
- Increased thrombosis risk
- Potential haemorrhage due to abnormal platelet function
- Persistent thrombocytosis – Management:
- Early haematology referral
- Aspirin
- Cardiovascular risk management
- Cytotoxic
Myelofibrosis – Features:
- Fibrotic tissue replacing normal bone marrow
- Extramedullary haematopoiesis in spleen and liver
- Predominantly affects elderly – Symptoms:
- Anaemia
- Malaise
- Fever
- Massive splenomegaly
- Gout – Blood film:
- Decreased Hb
- Immature erythroid and myeloid cells
- Teardrop-shaped red cells