Prophylactic Oral Macrolides

Prophylactic Oral Macrolides

• Azithromycin 500mg x3/wk
• Before starting: [ ECG (check for QTc prolongation), LFT’s] – both should be repeated 1 month after starting
• Oral macrolide therapy could be considered to reduce exacerbation frequency in adults (50– 70 years) with ongoing symptoms despite >80% adherence to high-dose inhaled steroids and at least one exacerbation requiring oral steroids in the past year.